Ed Evans

Simon

Having begun my scientific career with an undergraduate masters in biochemistry here at Oxford University, I was keen to work in the area of immunology, but researching at the molecular level. Thus, at the end of my studies in 1998 I immediately joined this laboratory to study for a D.Phil. under the supervision of Simon Davis. I began my doctoral research looking at the nature of protein-protein interactions at the leukocyte cell surface, focusing on the CD2 subset of the immunoglobulin superfamily. The complex network of such interactions that regulate the cells of the immune system fascinated me and, after my initial work on individual molecules, I began to assess the extent of this complexity across the whole T-cell surface using expression analysis and bioinformatic approaches. After completing my D.Phil. in 2002, I elected to remain here in order to continue my research on both fronts: detailed analyses of important individual molecules or interactions and global analyses of the components involved in complex processes such as T-cell activation. I am currently involved with the day-to-day management of the T-cell biology group as well as continuing to undertake gene expression analysis (using SAGE), structural biology and molecular interaction studies (using a BIAcore 3000) towards our aim of elucidating the mechanisms by which T-cells are activated, regulated and inhibited. Outside of my scientific work, I have a strong Christian faith and now lead the Abingdon Community Church.