Systematic review of PPI and H2A in GORD - Contents
Reflux oesophagitis: quantitative systematic review of the evidence of effectiveness of proton pump inhibitors and histamine antagonists
Introduction
WHAT IS REFLUX OESOPHAGITIS?
Symptoms
Risk factors
Oesophageal damage
Oesophagitis and cancer
Cause of reflux
PREVALENCE AND NATURAL HISTORY
Prevalence
Natural history
TREATMENT OPTIONS
Lifestyle change
Antacids and alginates
Mucoaprotective agents
Motility stimulants
Suppression of acid secretion
Antireflux surgery
Treatment choices
Maintenance
Systematic review methods
LAbbé plot
NNT
SEARCHING
DATA ABSTRACTION
Data analysis
Systematic review results
SHORT-TERM HEALING
Omeprazole compared with ranitidine
Omeprazole compared with cimetidine
Lanzoprazole compared with ranitidine
Healing - All PPI vs all H2A
Adverse events - All PPI vs all H2A
PPI - other comparisons with H2A
PPI comparisons
PPI comparisons with placebo
H2A comparisons with placebo
LONG-TERM HEALING
Omeprazole compared with ranitidine
Omeprazole compared with placebo
Lanzoprazole compared with placebo
Systematic review discussion
Short-term healing
Long-term maintenance
References
FIGURE 1: NNT CALCULATION
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FIGURE 5: